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Health Condition(s) or Problem
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Malignant pleural mesothelioma (MPM)
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Lay Summary
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http://cancerhelp.cancerresearchuk.org/trials/a-study-find-out-radiotherapy-help-control-pain-people-mesothelioma (from ISRCTN)
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Who can enter the trial
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1. >/=18 years of age.
2. Histological or multi-disciplinary team (MDT) diagnosis of mesothelioma
3. Able to complete study assessments
3. Life expectancy of at least 3 months based on clinical judgement
4. Due to receive radiotherapy for pain resulting from mesothelioma (defined as index site ? site of radiotherapy)
5. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
6. CT scan within 6 weeks of radiotherapy
7. Worst pain >4/10 (0-10 Visual Analogue Scale) corresponding to the index site
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Who cannot enter the trial
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1. Received chemotherapy or radiotherapy in the preceding six weeks that is likely to alter pain at the index site during the duration of the study
2. Planned chemotherapy during the period of the study that is likely to alter pain during the course of the study
3. Psychotic disorders or cognitive impairment
4. Co-existing lung tumours at the time of study entry
5. Pregnant or breastfeeding
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What will happen
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The symtoms will be measured using validated questionnaires at end of radiotherapy treatment (week 1), at week 5 and week 12 (final study visit)
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Primary aim
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This research will assess if radiotherapy is beneficial in treating pain in malignant pleural mesothelioma (MPM).
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Secondary Aim
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1. To assess whether radiotherapy improves other symptoms (dyspnoea, fatigue, distress) using a number of validated questionnaires
2. Possible biomarkers will be examined and the relationship between inflammation and symptoms explored
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Participant Information Sheet
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Not available in web format, please use the contact details below to request a patient information sheet
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Website
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Sorry, not currently available
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Recruitment Status
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Recruiting
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Nation
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Scotland
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Location
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Edinburgh
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