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Health Condition(s) or Problem
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Iron deficiency anaemia
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Lay Summary
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Sorry, not currently available
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Who can enter the trial
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1. Females aged 18 to 50 years
2. Iron deficiency anaemia, defined as haemoglobin less than 12 g/dl, and mean corpuscular volume (MCV) less than 90 fl and serum ferritin less than 20 ug/l
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Who cannot enter the trial
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1. Suffer from serious chronic illness
2. Body mass index above 30
3. Smoker
4. Taking prescription drugs including contraceptive medicines
5. Regularly take medicines containing aspirin or ibuprofen
6. Pregnant or breastfeeding or are planning to become pregnant in the next two months
7. Moderately/severely elevated cholesterol (more than 6.0 mmol/l), as these factors affect either iron absorption or plasma isoprostane concentration
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What will happen
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Subjects with iron deficiency anaemia will be recruited and will be randomly assigned to either a treatment (n = 15) or control group (n = 15). Subjects in the treatment group will receive 200 mg FeSO4 (65 mg iron) once daily for 28 days. Controls will NOT receive a placebo, but will be instructed not to change their diet/lifestyle habits over a period of 28 days. In these subjects, plasma isoprostanes and serum NTBI will be measured at the start of the start of the study, and 28 days after their allocation to the control group.
All subjects will be asked to complete a seven day estimated diet diary, starting on the day after their allocation to either the treatment or control group, in order to examine the relationship between dietary antioxidant intakes and isoprostane levels in all subjects.
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Primary aim
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Plasma isoprostane concentration after daily iron treatment for 28 days.
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Secondary Aim
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The secondary outcome is serum NTBI. In addition to measuring the primary outcome (plasma isoprostanes) before and once after once daily ferrous sulphate treatment for 28 days, we will also measure serum NTBI before and once after daily ferrous sulphate treatment for 28 days in all subjects.
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Participant Information Sheet
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Sorry, not currently available
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Website
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Sorry, not currently available
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Recruitment Status
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Stopped
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Nation
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England
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Location
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London
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