|
Health Condition(s) or Problem
|
Brain and Central Nervous System Tumors
|
|
Lay Summary
|
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor
cells. Combining more than one drug and combining chemotherapy with radiation therapy may
kill more tumor cells.
PURPOSE: This phase II trial is studying combination chemotherapy and radiation therapy to
see how well they work in treating children with localized ependymoma.
(from ClinicalTrials.gov)
|
|
Who can enter the trial
|
DISEASE CHARACTERISTICS:
- Histologically proven nonmetastatic intracranial ependymoma
- Cellular
- Papillary
- Clear cell
- Mixed cell
- Anaplastic
- No myxopapillary ependymoma, subependymoma, or ependymoblastoma
PATIENT CHARACTERISTICS:
Age:
- 3 to 20
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- No hematologic disease that would preclude study participation
Hepatic:
- Not specified
Renal:
- No renal disease that would preclude study participation
Other:
- No concurrent unrelated disease that would preclude study participation
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- Prior steroids allowed
Radiotherapy:
- No prior radiotherapy
Surgery:
- Not specified
|
|
Who cannot enter the trial
|
DISEASE CHARACTERISTICS:
- Histologically proven nonmetastatic intracranial ependymoma
- Cellular
- Papillary
- Clear cell
- Mixed cell
- Anaplastic
- No myxopapillary ependymoma, subependymoma, or ependymoblastoma
PATIENT CHARACTERISTICS:
Age:
- 3 to 20
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- No hematologic disease that would preclude study participation
Hepatic:
- Not specified
Renal:
- No renal disease that would preclude study participation
Other:
- No concurrent unrelated disease that would preclude study participation
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- Prior steroids allowed
Radiotherapy:
- No prior radiotherapy
Surgery:
- Not specified
|
|
What will happen
|
Drug; cyclophosphamide; Drug; etoposide; Drug; vincristine sulfate; Procedure; adjuvant therapy; Procedure; conventional surgery; Radiation; radiation therapy
|
|
Primary aim
|
Event-free survival; Overall survival; Surgical operability; Response rate
|
|
Secondary Aim
|
Sorry, not currently available
|
|
Participant Information Sheet
|
Sorry, not currently available
|
|
Website
|
http://cancer.gov/clinicaltrials/SIOP-EPENDYMOMA-99
|
|
Recruitment Status
|
Recruiting
|
|
Nation
|
England
|
|
Location
|
Birmingham
|