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Health Condition(s) or Problem
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Hereditary Multiple Melanoma; Melanoma (Skin)
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Lay Summary
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RATIONALE: Identifying gene mutations and other risk factors in patients with melanoma and
in families with a history of hereditary melanoma may help doctors identify persons at risk
for melanoma and other types of cancer. It may also help the study of cancer in the future.
PURPOSE: This clinical trial is studying gene mutations in patients with melanoma and in
families with a history of hereditary melanoma.
(from ClinicalTrials.gov)
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Who can enter the trial
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DISEASE CHARACTERISTICS:
- Meets one of the following criteria:
- Prior multiple primary melanomas
- Histological samples available
- Family history of melanoma, with melanoma in two first-degree relatives (e.g.,
cases of melanoma in both a mother and son or in two brothers but not in two
cousins)
- Family history of melanoma, where three or more individuals (of any
relationship) have had melanoma
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
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Who cannot enter the trial
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DISEASE CHARACTERISTICS:
- Meets one of the following criteria:
- Prior multiple primary melanomas
- Histological samples available
- Family history of melanoma, with melanoma in two first-degree relatives (e.g.,
cases of melanoma in both a mother and son or in two brothers but not in two
cousins)
- Family history of melanoma, where three or more individuals (of any
relationship) have had melanoma
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
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What will happen
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Genetic; gene expression analysis; Genetic; microarray analysis; Genetic; molecular genetic technique; Genetic; mutation analysis; Other; laboratory biomarker analysis; Procedure; mutation carrier screening; Procedure; study of high risk factors
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Primary aim
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Predictive significance of melanoma susceptibility gene (MSG) mutations in the CDKN2A gene; Susceptibility to other types of cancer as a feature of MSG mutations; Risk of other types of cancers in mutation carriers; Environmental exposures, in particular sun exposure, that modify risk of melanoma in MSG mutation carriers
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Secondary Aim
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Sorry, not currently available
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Participant Information Sheet
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Sorry, not currently available
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Website
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Sorry, not currently available
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Recruitment Status
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Recruiting
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Nation
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England
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Location
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Leeds
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