Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom

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  • Source

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    Public Title Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom
    Acronym Sorry, not currently available
    Source of Record URL http://clinicaltrials.gov/show/NCT00757263

  • Trial

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    Health Condition(s) or Problem Ovarian Cancer
    Lay Summary RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility for cancer and interactions between genes and the environment in patients with ovarian cancer. (from ClinicalTrials.gov)
    Who can enter the trial DISEASE CHARACTERISTICS: - Diagnosis of ovarian cancer within the past 5 years - Identified through the East Anglia, Stoke and West Midlands Cancer Registries serving any of the following geographic regions of the United Kingdom: - East Anglia - Oxford - Trent - West Midlands PATIENT CHARACTERISTICS: - Identified by the patient's general practitioner as fit to contact for this study - No serious mental illness or retardation PRIOR CONCURRENT THERAPY: - Not specified
    Who cannot enter the trial DISEASE CHARACTERISTICS: - Diagnosis of ovarian cancer within the past 5 years - Identified through the East Anglia, Stoke and West Midlands Cancer Registries serving any of the following geographic regions of the United Kingdom: - East Anglia - Oxford - Trent - West Midlands PATIENT CHARACTERISTICS: - Identified by the patient's general practitioner as fit to contact for this study - No serious mental illness or retardation PRIOR CONCURRENT THERAPY: - Not specified
    What will happen Genetic; polymorphism analysis; Other; laboratory biomarker analysis; Other; questionnaire administration
    Primary aim Acquisition of epidemiological information and biological material; Proportion of ovarian cancer incidence attributable to mutations in known predisposing genes (e.g., BRCA1 and BRCA2); Risk associated with predisposing mutations; Effect of nongenetic risk factors in mutation carriers; Pathological and clinical characteristics of ovarian cancers occurring in BRCA1/2 mutation carriers as compared with that in noncarriers; Exploration of mutations at other loci that may predispose to ovarian cancer
    Secondary Aim Sorry, not currently available
    Participant Information Sheet Sorry, not currently available
    Website http://cancer.gov/clinicaltrials/MREC-SEARCH-OVARIAN
    Recruitment Status Recruiting
    Nation England
    Location Cambridge

  • Contact

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    Contact for Public Queries Paul Pharoah, MD Study Chair Cancer Research UK
    Contact for Scientific Queries Sorry, not currently available
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