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Health Condition(s) or Problem
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Melanoma (Skin)
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Lay Summary
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RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help the study of cancer in the future.
PURPOSE: This laboratory study is looking at tumor tissue samples from patients with
melanoma who have undergone sentinel lymph node biopsy.
(from ClinicalTrials.gov)
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Who can enter the trial
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DISEASE CHARACTERISTICS:
- Confirmed diagnosis of cutaneous melanoma
- Breslow thickness > 0.75 mm
- Has undergone sentinel lymph node biopsy
- No primary melanoma that has not originated in the skin
- No multiple primary melanomas
- Currently under clinical followup OR discharged from follow up within the past 3
months
PATIENT CHARACTERISTICS:
- No other malignancy except for nonmelanoma skin cancer or cervical carcinoma in situ
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
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Who cannot enter the trial
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DISEASE CHARACTERISTICS:
- Confirmed diagnosis of cutaneous melanoma
- Breslow thickness > 0.75 mm
- Has undergone sentinel lymph node biopsy
- No primary melanoma that has not originated in the skin
- No multiple primary melanomas
- Currently under clinical followup OR discharged from follow up within the past 3
months
PATIENT CHARACTERISTICS:
- No other malignancy except for nonmelanoma skin cancer or cervical carcinoma in situ
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
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What will happen
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Genetic; gene expression analysis; Genetic; mutation analysis; Other; diagnostic laboratory biomarker analysis; Other; immunohistochemistry staining method; Procedure; sentinel lymph node biopsy
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Primary aim
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Predictive model for sentinel lymph node biopsy positivity; Survival model for relapse; Genetic determinants in primary melanomas that predict a metastatic phenotype
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Secondary Aim
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Sorry, not currently available
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Participant Information Sheet
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Sorry, not currently available
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Website
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Sorry, not currently available
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Recruitment Status
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Recruiting
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Nation
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England
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Location
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Leeds
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