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Health Condition(s) or Problem
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Osteoarthritis of the Knee
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Lay Summary
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The aim is to improve understanding of the assessment of pain experience in patients with
osteoarthritis (OA) of the knee. The current study will be divided into two parts. In Study
1, the investigators will analyse existing questionnaires relevant to the mechanisms and
therapeutic targets of knee OA to establish discrete dimensions that discriminate between
the different mechanisms of pain. On the basis of this analysis, the investigators will
refine the questionnaires to maximise their sensitivity to knee OA. In Study 2, the
investigators will seek to confirm the factor structure identified in the questionnaires in
Study 1 and explore potential mediator and moderator variables between pain and quality of
life using the refined measures. The investigators will also evaluate Quantitative Sensory
Testing as a predictor of OA knee pain.
(from ClinicalTrials.gov)
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Who can enter the trial
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Inclusion Criteria:
- Participants in Study 1 will have OA of the knee defined and scored radiologically
and will report knee pain. Participants in Study 2 will also have OA of the knee, but
a clinical diagnosis will suffice.
Exclusion Criteria:
- Inability to speak or understand English
- Under the age of 18 years old
- knee joint surgery within three months prior to participation
- Diagnosed Rheumatoid Arthritis, Psoriatic Arthritis, Gout or any other inflammatory
arthritis disorder
- The participants in Study 2 will also be excluded if they participated in Study 1
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Who cannot enter the trial
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Inclusion Criteria:
- Participants in Study 1 will have OA of the knee defined and scored radiologically
and will report knee pain. Participants in Study 2 will also have OA of the knee, but
a clinical diagnosis will suffice.
Exclusion Criteria:
- Inability to speak or understand English
- Under the age of 18 years old
- knee joint surgery within three months prior to participation
- Diagnosed Rheumatoid Arthritis, Psoriatic Arthritis, Gout or any other inflammatory
arthritis disorder
- The participants in Study 2 will also be excluded if they participated in Study 1
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What will happen
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Other; Questionnaires; Patients will be given questionnaires relevant to their condition to complete. In Study 2 and a sub-study of Study 1, patients will be invited to take part in Quantitative Sensory Testing.; Knee osteoarthritis
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Primary aim
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Questionnaire set assessing physical symptoms, cognitive and emotional factors, and quality of life in knee OA.
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Secondary Aim
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Quantitative Sensory Testing assessing pain and sensory thresholds for a noxious stimulus (Pain Pressure Thresholds); Patients will be assessed after diagnosis of OA of the knee. There is no specific time point after diagnosis, because we are interested in a broad spectrum of patients with OA of the knee.; No; Pain and sensory thresholds will be reported for the affected area (i.e., OA knee) and control areas (e.g., healthy contralateral knee).
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Participant Information Sheet
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Sorry, not currently available
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Website
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http://www.nottingham.ac.uk/paincentre/index.aspx
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Recruitment Status
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Recruiting
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Nation
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England
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Location
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Nottingham
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