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Health Condition(s) or Problem
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Osteoarthritis
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Lay Summary
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Osteoarthritis is by far the most common joint condition and the single largest cause of
disability in the older population. The investigators still have a poor understanding of the
nature of osteoarthritis and factors that influence its development and progression.
Identification of biochemical markers that relate to cartilage loss, bony overgrowth and
other features that occur with osteoarthritis will advance our understanding. Over the last
5 years analytical methods have developed to measure a range of different biomarkers. This
pilot study will use these analytical methods to measure biomarker levels in joint fluid,
urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers.
This study will provide novel pilot data on the changes in the composition of the synovial
fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the
knee is a suitable joint for study because of its accessibility to clinical assessment,
joint aspiration and imaging.
(from ClinicalTrials.gov)
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Who can enter the trial
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Inclusion Criteria:
All participants:
- Be able to provide written informed consent
- Aged 30 and over
Knee OA patients:
• Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at
least one compartment of the knee
Normal controls:
- No knee pain
- No clinical or radiographic changes of knee OA
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Who cannot enter the trial
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Inclusion Criteria:
All participants:
- Be able to provide written informed consent
- Aged 30 and over
Knee OA patients:
• Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at
least one compartment of the knee
Normal controls:
- No knee pain
- No clinical or radiographic changes of knee OA
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What will happen
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Sorry, not currently available
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Primary aim
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Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees.
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Secondary Aim
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Sorry, not currently available
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Participant Information Sheet
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Sorry, not currently available
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Website
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Sorry, not currently available
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Recruitment Status
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Completed
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Nation
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England
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Location
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Nottingham
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