Randomised controlled trial of brief cognitive therapy for posttraumatic stress disorder (PTSD) | Not Recruiting
Randomised controlled trial of brief cognitive therapy for posttraumatic stress disorder (PTSD)
CTPTSD
Trial Source

There is no location for this trial

Location data is sourced from multiple external providers and UKCTG is not responsible for and cannot guarantee the accuracy of data.

Health Conditions
  • Posttraumatic stress disorder
Primary Contact Details
Not Recruiting
Recruitment Status
ISRCTN30480505
Primary Trial ID Number
Summary
Background and study aims: Recent research indicates that posttraumatic stress disorder can be treated effectively. The study compares two forms of a psychological treatment for posttraumatic stress disorder named Cognitive Therapy for PTSD. There is already evidence that this treatment is effective, but we do not know what way of delivering the treatment is the most effective and most acceptable to patients. Who can participate? Adults suffering from posttraumatic stress disorder as a result of traumas in adulthood (e.g., assault, accidents, disaster) who can regularly attend treatment sessions either in South London or Oxford. What does the study involve? Participants will receive one of the two forms of psychological treatment for posttraumatic stress disorder that are being compared in the study. No drugs are involved in the treatment. Two thirds of the participants will start treatment right away. The remaining third will wait 3 months before starting treatment, and will then receive one of the forms of psychological treatment. The decision about which treatment participants receive and when they start treatment will be made by chance. In the first three months of treatment, participants receive either up to 12 weekly sessions with a therapist or up to 6 sessions with a therapist and 6 home sessions where they work through the therapy materials at their own pace. In the following three months, they receive either up to 3 or up to 2 further sessions with the therapist. Before and after treatment (or waiting for treatment), participants complete a number of assessments to monitor their improvement. They are interviewed and asked to fill in a number of questionnaires before, midway through and after the first three months of treatment, and three months, six months, one year and two years later. What are the possible benefits and risks of participating? All participants will receive an effective psychological treatment. The treatment involves talking and writing about the participants' memories of their trauma, and participants may experience short-term distress when confronting their memories. The discussion of the traumatic experience will be handled with sensitivity. Previous results showed that the treatment is well tolerated. Where is the study run from? 1. Centre for Anxiety Disorders and Trauma, South London and Maudsley NHS Foundation Trust, London in collaboration with the Institute of Psychiatry, King's College London. 2. Oxford Centre for Anxiety Disorders and Trauma, University of Oxford When is the study starting and how long is it expected to run for? Recruitment started October 2010. Anticipated end of recruitment: July 2013. Who is funding the study? The Wellcome Trust (UK). Who is the main contact? Jennifer Readings jennifer.readings@kcl.ac.uk
Research Details
  • Brief self-study assisted cognitive therapy for posttraumatic stress disorder (PTSD) is effective.
Phase
Sorry, this information is not available
Study Design
Randomised controlled trial
Study Type
Interventional
Intervention

1. Brief self-study assisted cognitive therapy for PTSD: up to 12 weekly sessions over 13 weeks, plus up to 3 sessions over next 3 months, last follow-up 2 years after end of weekly sessions 2. Standard cognitive therapy for PTSD: up to 6 sessions over 13 weeks, plus up to 2 sessions over next 3 months, follow-up 2 years after 13 week assessment 3. Wait list: 13 weeks wait, then random allocation to either standard or brief CT

Intervention Type
Behavioural
Primary Outcome Measures
  • Measured at initial assessment and 13, 26, 39, 65 and 117 weeks:
  • 1. Clinician-Administered PTSD Scale (CAPS)
  • 2. Posttraumatic Diagnostic Scale (PDS)
  • 3. Percent meeting DSM-IV criteria for PTSD
Secondary Outcome Measures
  • Measured at initial assessment and 13, 26, 39, 65 and 117 weeks:
  • 1. Beck Depression Inventory
  • 2. Beck Anxiety Inventory
  • 3. Work and Social Adjustment Scale
  • 4. Endicott Quality of Life Scale
  • 5. Client Satisfaction Questionnaire
Publication(s)
Sorry, this information is not available
Result Reports
Sorry, this information is not available
Gender
Both
Age Range
Adult
Who Can Participate
Patient
Number of Participants
90
Participant Inclusion Criteria
  • 1. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) diagnosis of PTSD
  • 2. Current PTSD is linked to 1 to 2 discrete traumas
  • 3. PTSD is the main mental health problem requiring treatment
  • 4. Willing to accept random allocation
  • 5. Aged 18 years and above, either sex
Participant Exclusion Criteria
  • 1. Current substance dependence
  • 2. Immediate suicide risk
  • 3. Borderline personality disorder requiring treatment in its own right
  • 4. History of psychosis
  • 5. No memory for the trauma
  • 6. Unable to conduct the therapy in English
  • 7. Serious ongoing threat (e.g. still living with perpetrator)
Trial Location(s)
London
SE5 8AF
Trial Contact(s)
Primary Trial Contact
Prof Anke Ehlers
Other Trial Contacts
Sorry, this information is not available
Countries Recruiting
United Kingdom
Scientific Title
A randomised controlled trial of brief self-study assisted and standard cognitive therapy for posttraumatic stress disorder
EudraCT Number
Sorry, this information is not available
Funder(s)
  • Wellcome Trust
Other Study ID Numbers
069777
Sponsor(s)
Institute of Psychiatry, Kings College London (UK)
Key Dates

Recruitment Start Date

01 Oct 2010

Recruitment End Date

01 Jul 2013

Trial Start Date

07 Sep 2010

Trial End Date

31 Oct 2015

Date Assigned

22 Oct 2010

Last Updated

03 Feb 2015