Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom | Recruiting
Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom

Trial Source

There is no location for this trial

Location data is sourced from multiple external providers and UKCTG is not responsible for and cannot guarantee the accuracy of data.

Health Conditions
  • Ovarian Cancer
Unfortunately contact details are not available for this trial.
Primary Contact Details
Recruiting
Recruitment Status
NCT00757263
Primary Trial ID Number
Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility for cancer and interactions between genes and the environment in patients with ovarian cancer.
Research Details
  • OBJECTIVES: - To obtain epidemiological information and biological material on a population-based series of ovarian cases. - To define the proportion of ovarian cancer incidence attributable to mutations in known predisposing genes (e.g., BRCA1 and BRCA2). - To determine the risk associated with predisposing mutations by examining the cancer risks in relatives of patients who are shown to be carriers. - To examine the effect of nongenetic risk factors in mutation carriers. - To determine the pathological and clinical characteristics of ovarian cancers occurring in BRCA1/2 mutation carriers as compared with that in noncarriers. - To establish whether mutations at other loci may predispose to ovarian cancer by comparing the frequency of alterations in ovarian cancer patients with that in cancer-free controls identified through the European Prospective Investigation of Cancer (EPIC) study. OUTLINE: This is a multicenter study. Patients complete an epidemiological questionnaire. The questionnaire will request identifying information on the patient's first-degree relatives. Blood samples are collected from patients. DNA is extracted from these blood samples and from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL as well as from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes. In addition to the ovarian cancer patients recruited for this study, patients with breast, endometrial, prostate, colorectal, bladder, kidney, pancreatic, brain and esophageal cancer, malignant melanoma, and lymphoma cancer are recruited in the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-PROSTATE, MREC-SEARCH-COLORECTAL, and MREC-SEARCH-CANCER.
Phase
N/A
Study Design
N/A
Study Type
Observational
Intervention
Genetic : polymorphism analysis, Other : laboratory biomarker analysis, Other : questionnaire administration

Study Arm Groups : , ,

Intervention Type
See Interventions above
Primary Outcome Measures
  • Acquisition of epidemiological information and biological material; null; Proportion of ovarian cancer incidence attributable to mutations in known predisposing genes (e.g., BRCA1 and BRCA2); null; Risk associated with predisposing mutations; null; Effect of nongenetic risk factors in mutation carriers; null; Pathological and clinical characteristics of ovarian cancers occurring in BRCA1/2 mutation carriers as compared with that in noncarriers; null; Exploration of mutations at other loci that may predispose to ovarian cancer; null
Secondary Outcome Measures
    Sorry, this information is not available
Publication(s)
Sorry, this information is not available
Result Reports
This is available on the Clinicaltrials.gov website
Gender
Both
Age Range
18 Years - 74 Years
Who Can Participate
Patients
Number of Participants
2000
Participant Inclusion Criteria
  • DISEASE CHARACTERISTICS:
  • - Diagnosis of ovarian cancer within the past 5 years
  • - Identified through the East Anglia, Stoke and West Midlands Cancer Registries serving
  • any of the following geographic regions of the United Kingdom:
  • - East Anglia
  • - Oxford
  • - Trent
  • - West Midlands
  • PATIENT CHARACTERISTICS:
  • - Identified by the patient's general practitioner as fit to contact for this study
  • - No serious mental illness or retardation
  • PRIOR CONCURRENT THERAPY:
  • - Not specified
Participant Exclusion Criteria
This is in the inclusion criteria above
Trial Location(s)
University of Cambridge Cancer Research UK
Cambridge
England
CB1 8RN
Trial Contact(s)
Primary Trial Contact
Sorry, this information is not available
Other Trial Contacts
Sorry, this information is not available
Countries Recruiting
United Kingdom
Scientific Title
A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Ovarian Cancer in East Anglia, Oxford, Trent and West Midlands
EudraCT Number
Not available for this trial
Funder(s)
    Sorry, this information is not available
Other Study ID Numbers
CDR0000598881
Sponsor(s)
Cancer Research UK
Key Dates

Recruitment Start Date

Feb 2008

Recruitment End Date
Date Not Available
Trial Start Date
Date Not Available
Trial End Date
Date Not Available
Date Assigned

22 Sep 2008

Last Updated

23 Aug 2013