Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom | Recruiting
Study of Genes and the Environment in Patients With Ovarian Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom
Health Conditions
  • Ovarian Cancer
Recruiting
Recruitment Status
NCT00757263
Primary Trial ID Number
Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility for cancer and interactions between genes and the environment in patients with ovarian cancer.
Primary Outcome Measures
  • Acquisition of epidemiological information and biological material; null; Proportion of ovarian cancer incidence attributable to mutations in known predisposing genes (e.g., BRCA1 and BRCA2); null; Risk associated with predisposing mutations; null; Effect of nongenetic risk factors in mutation carriers; null; Pathological and clinical characteristics of ovarian cancers occurring in BRCA1/2 mutation carriers as compared with that in noncarriers; null; Exploration of mutations at other loci that may predispose to ovarian cancer; null
Secondary Outcome Measures
    Sorry, this information is not available
Research Question
  • RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility for cancer and interactions between genes and the environment in patients with ovarian cancer.
Design Type
Sorry, this information is not available
Ethics Approval
Sorry, this information is not available
Publications
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Countries of Recruitment
United Kingdom
Participant Sex
Both
Participant Age Range
18 Years to 74 Years
Participant Type
Sorry, this information is not available
Trial Sample Size
2000
Participant Inclusion Criteria
  • DISEASE CHARACTERISTICS:
  • - Diagnosis of ovarian cancer within the past 5 years
  • - Identified through the East Anglia, Stoke and West Midlands Cancer Registries serving
  • any of the following geographic regions of the United Kingdom:
  • - East Anglia
  • - Oxford
  • - Trent
  • - West Midlands
  • PATIENT CHARACTERISTICS:
  • - Identified by the patient's general practitioner as fit to contact for this study
  • - No serious mental illness or retardation
  • PRIOR CONCURRENT THERAPY:
  • - Not specified
Participant Exclusion Criteria
  • DISEASE CHARACTERISTICS:
  • - Diagnosis of ovarian cancer within the past 5 years
  • - Identified through the East Anglia, Stoke and West Midlands Cancer Registries serving
  • any of the following geographic regions of the United Kingdom:
  • - East Anglia
  • - Oxford
  • - Trent
  • - West Midlands
  • PATIENT CHARACTERISTICS:
  • - Identified by the patient's general practitioner as fit to contact for this study
  • - No serious mental illness or retardation
  • PRIOR CONCURRENT THERAPY:
  • - Not specified
Interventions
Genetic; polymorphism analysis; null; []; Other; laboratory biomarker analysis; null; []; Other; questionnaire administration; null; []
Design Details
Sorry, this information is not available
Study Design
N/A
Results Reporting
Sorry, this information is not available
Acronym
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Scientific Title
A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Ovarian Cancer in East Anglia, Oxford, Trent and West Midlands
Secondary Trial Identifying Number
MREC-SEARCH-OVARIAN; MREC-07/MRE05/17
Website
http://cancer.gov/clinicaltrials/MREC-SEARCH-OVARIAN
Study Funded By
Cancer Research UK
Funder Type
Sorry, this information is not available
Study Sponsored By
Cancer Research UK
Study Also Sponsored By
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Primary Sponsor Type
Sorry, this information is not available
Secondary Sponsor Type
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Key Dates

Date of First Enrollment
Date Not Available
Recruitment End Date
Date Not Available
Trial End Date
Date Not Available
Date added to Registry

22 Sep 2008

Last Updated

23 Aug 2013

Date Record Refreshed on UKCTG

31 Jul 2015