Studying Tumor Tissue Samples From Patients With Melanoma Who Have Undergone Sentinel Lymph Node Biopsy | Recruiting
Studying Tumor Tissue Samples From Patients With Melanoma Who Have Undergone Sentinel Lymph Node Biopsy
Health Conditions
  • Melanoma (Skin)
Recruiting
Recruitment Status
NCT00897481
Primary Trial ID Number
Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at tumor tissue samples from patients with melanoma who have undergone sentinel lymph node biopsy.
Primary Outcome Measures
  • Predictive model for sentinel lymph node biopsy positivity; null; Survival model for relapse; null; Genetic determinants in primary melanomas that predict a metastatic phenotype; null
Secondary Outcome Measures
    Sorry, this information is not available
Research Question
  • RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at tumor tissue samples from patients with melanoma who have undergone sentinel lymph node biopsy.
Design Type
Sorry, this information is not available
Ethics Approval
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Publications
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Countries of Recruitment
United Kingdom
Participant Sex
Both
Participant Age Range
N/A to N/A
Participant Type
Sorry, this information is not available
Trial Sample Size
1000
Participant Inclusion Criteria
  • DISEASE CHARACTERISTICS:
  • - Confirmed diagnosis of cutaneous melanoma
  • - Breslow thickness > 0.75 mm
  • - Has undergone sentinel lymph node biopsy
  • - No primary melanoma that has not originated in the skin
  • - No multiple primary melanomas
  • - Currently under clinical followup OR discharged from follow up within the past 3
  • months
  • PATIENT CHARACTERISTICS:
  • - No other malignancy except for nonmelanoma skin cancer or cervical carcinoma in situ
  • PRIOR CONCURRENT THERAPY:
  • - See Disease Characteristics
Participant Exclusion Criteria
  • DISEASE CHARACTERISTICS:
  • - Confirmed diagnosis of cutaneous melanoma
  • - Breslow thickness > 0.75 mm
  • - Has undergone sentinel lymph node biopsy
  • - No primary melanoma that has not originated in the skin
  • - No multiple primary melanomas
  • - Currently under clinical followup OR discharged from follow up within the past 3
  • months
  • PATIENT CHARACTERISTICS:
  • - No other malignancy except for nonmelanoma skin cancer or cervical carcinoma in situ
  • PRIOR CONCURRENT THERAPY:
  • - See Disease Characteristics
Interventions
Genetic; gene expression analysis; null; []; Genetic; mutation analysis; null; []; Other; diagnostic laboratory biomarker analysis; null; []; Other; immunohistochemistry staining method; null; []; Procedure; sentinel lymph node biopsy; null; []
Design Details
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Study Design
N/A
Results Reporting
Sorry, this information is not available
Acronym
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Scientific Title
A Retrospective Case-Control Study of Melanoma Patients Who Have Undergone Sentinel Lymph Node Biopsy
Secondary Trial Identifying Number
CDR0000532943; EU-20706
Website
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Study Funded By
Leeds Cancer Centre at St. James's University Hospital
Funder Type
Sorry, this information is not available
Study Sponsored By
Leeds Cancer Centre at St. James's University Hospital
Study Also Sponsored By
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Primary Sponsor Type
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Secondary Sponsor Type
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Key Dates

Date of First Enrollment
Date Not Available
Recruitment End Date
Date Not Available
Trial End Date
Date Not Available
Date added to Registry

09 May 2009

Last Updated

09 Aug 2013

Date Record Refreshed on UKCTG

31 Jul 2015