An Exploration of Genetic Testing for Prostate Cancer Susceptibility | Recruiting
An Exploration of Genetic Testing for Prostate Cancer Susceptibility
Health Conditions
  • Prostate Cancer
Recruiting
Recruitment Status
NCT00997464
Primary Trial ID Number
Summary
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
Primary Outcome Measures
  • Whether cancer worry changes between the two time-points (measured using the Impact of Event Scale); null
Secondary Outcome Measures
  • Why are men interested/ not interested in seeking genetic profiling for prostate cancer, and what might be the uptake of such testing?; null; What are the expectations of this testing from the perspective of the user, what are the perceived benefits and limitations of testing and how do these change through the testing process; null; Is there a relationship between a family history of cancer, cancer worry, and a persons intention to seek genetic testing?; null; How would the information provided by such a test be used by the individual and the family and how could this impact upon the healthcare system; null
Research Question
  • Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
Design Type
Sorry, this information is not available
Ethics Approval
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Publications
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Countries of Recruitment
United Kingdom
Participant Sex
Male
Participant Age Range
40 Years to 69 Years
Participant Type
Sorry, this information is not available
Trial Sample Size
200
Participant Inclusion Criteria
  • Inclusion Criteria:
  • - Men with a positive family history of prostate cancer. The definition of a positive
  • family history will be: Men with a first degree relative with prostate cancer
  • diagnosed at <70 years; Men with two relatives with prostate cancer where at least on
  • is diagnosed at <70 years; Men with three relatives with prostate cancer diagnosed at
  • any age
  • - Age 40-69 years
  • - No previous biopsy for raised PSA
  • - Absence of any psychological, familial, sociological or geographic situation
  • potentially hampering compliance with the study protocol and follow-up schedule.
  • Exclusion Criteria:
  • - Previous prostate cancer
  • - Men from families where there is known to be a mutation in a high-risk prostate
  • cancer gene
  • - Men who have had a prostate biopsy within the last 12 months.
Participant Exclusion Criteria
  • Inclusion Criteria:
  • - Men with a positive family history of prostate cancer. The definition of a positive
  • family history will be: Men with a first degree relative with prostate cancer
  • diagnosed at <70 years; Men with two relatives with prostate cancer where at least on
  • is diagnosed at <70 years; Men with three relatives with prostate cancer diagnosed at
  • any age
  • - Age 40-69 years
  • - No previous biopsy for raised PSA
  • - Absence of any psychological, familial, sociological or geographic situation
  • potentially hampering compliance with the study protocol and follow-up schedule.
  • Exclusion Criteria:
  • - Previous prostate cancer
  • - Men from families where there is known to be a mutation in a high-risk prostate
  • cancer gene
  • - Men who have had a prostate biopsy within the last 12 months.
Interventions
Sorry, this information is not available
Design Details
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Study Design
Observational Model: Cohort, Time Perspective: Prospective
Results Reporting
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Acronym
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Scientific Title
An Exploration of Factors Affecting Interest and Uptake of Genetic Testing for Prostate Cancer Susceptibility: The Clinical Application of Genetic Testing for Lower Risk Cancer Predisposition Genes
Secondary Trial Identifying Number
Sorry, this information is not available
Website
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Study Funded By
Royal Marsden NHS Foundation Trust
Funder Type
Sorry, this information is not available
Study Sponsored By
Royal Marsden NHS Foundation Trust
Study Also Sponsored By
Institute of Cancer Research, United Kingdom
Primary Sponsor Type
Sorry, this information is not available
Secondary Sponsor Type
Sorry, this information is not available
Key Dates

Date of First Enrollment
Date Not Available
Recruitment End Date
Date Not Available
Trial End Date
Date Not Available
Date added to Registry

16 Oct 2009

Last Updated

16 Oct 2009

Date Record Refreshed on UKCTG

31 Jul 2015