An Exploration of Genetic Testing for Prostate Cancer Susceptibility | Recruiting
An Exploration of Genetic Testing for Prostate Cancer Susceptibility

Trial Source

There is no location for this trial

Location data is sourced from multiple external providers and UKCTG is not responsible for and cannot guarantee the accuracy of data.

Health Conditions
  • Prostate Cancer
Primary Contact Details
Recruitment Status
Primary Trial ID Number
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
Research Details
  • This study will use a mixed methods approach to follow men as they move through the genetic testing process, from initial contact through to receiving their genetic testing results. A questionnaire will be used to measure variables at both baseline and after proceeding through the testing process. A small cohort of men will be invited to be interviewed to gather some in depth qualitative data about the issues that have arisen during the study process.
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Study Type
Sorry, this information is not available
Intervention Type
See Interventions above
Primary Outcome Measures
  • Whether cancer worry changes between the two time-points (measured using the Impact of Event Scale); null
Secondary Outcome Measures
  • Why are men interested/ not interested in seeking genetic profiling for prostate cancer, and what might be the uptake of such testing?; null; What are the expectations of this testing from the perspective of the user, what are the perceived benefits and limitations of testing and how do these change through the testing process; null; Is there a relationship between a family history of cancer, cancer worry, and a persons intention to seek genetic testing?; null; How would the information provided by such a test be used by the individual and the family and how could this impact upon the healthcare system; null
Sorry, this information is not available
Result Reports
This is available on the website
Age Range
40 Years - 69 Years
Who Can Participate
Sorry, this information is not available
Number of Participants
Participant Inclusion Criteria
  • Inclusion Criteria:
  • - Men with a positive family history of prostate cancer. The definition of a positive
  • family history will be: Men with a first degree relative with prostate cancer
  • diagnosed at <70 years; Men with two relatives with prostate cancer where at least on
  • is diagnosed at <70 years; Men with three relatives with prostate cancer diagnosed at
  • any age
  • - Age 40-69 years
  • - No previous biopsy for raised PSA
  • - Absence of any psychological, familial, sociological or geographic situation
  • potentially hampering compliance with the study protocol and follow-up schedule.
  • Exclusion Criteria:
  • - Previous prostate cancer
  • - Men from families where there is known to be a mutation in a high-risk prostate
  • cancer gene
  • - Men who have had a prostate biopsy within the last 12 months.
Participant Exclusion Criteria
This is in the inclusion criteria above
Trial Location(s)
Research Site
Trial Contact(s)
Primary Trial Contact
Dr Rosalind Eeles
Other Trial Contacts
Elizabeth Bancroft
Countries Recruiting
United Kingdom
Scientific Title
An Exploration of Factors Affecting Interest and Uptake of Genetic Testing for Prostate Cancer Susceptibility: The Clinical Application of Genetic Testing for Lower Risk Cancer Predisposition Genes
EudraCT Number
Not available for this trial
  • Institute of Cancer Research, United Kingdom
Other Study ID Numbers
Royal Marsden NHS Foundation Trust
Key Dates

Recruitment Start Date

Aug 2009

Recruitment End Date

Feb 2011

Trial Start Date
Date Not Available
Trial End Date
Date Not Available
Date Assigned

16 Oct 2009

Last Updated

16 Oct 2009