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Welcome to the UK Clinical Trials Gateway

Our site is here to help you find out about health and social care research that is taking place across the UK.

You can find out what 'clinical trials' and 'health and social care research' involves as well as finding out about studies that are happening right now into any condition or disease area.

Latest research findings

from the NIHR Dissemination Centre

The benefits of commonly used blood pressure and cholesterol lowering treatment can last 16 years
Fewer deaths from stroke had occurred in people who had high blood pressure treated with amlodipine, a calcium-channel blocker, compared to atenolol, 10 years after the end of a large trial. People with high blood pressure who took statins were less likely to die from cardiovascular diseases, such as heart disease or stroke than those taking a placebo. This study followed over 7,000 UK patients who had taken part in a clinical trial of blood pressure and cholesterol-lowering treatments between 1998 and 2005. It compared those who had been allocated to amlodipine with those who took atenolol. Those in either blood pressure group who had not already received a statin were also randomised to either atorvastatin (a cholesterol-lowering drug) or placebo. Some caution is needed in interpreting these findings because no details were available on what treatments were taken after the trial ended. Both arms of the original trial were stopped early because of the superiority of amlodipine-based treatment over atenolol-based treatment and atorvastatin over placebo. But it is likely that all groups received similar post-trial management according to best practice at the time. The results add important information for clinicians and patients considering the long-term implications of taking these medications.
15 January 2019

Home-based cardiac rehabilitation for heart failure has high rates of participation
Home-based cardiac rehabilitation for people with heart failure improves quality of life at 12 months compared with usual care. Among those allocated to rehabilitation, 90% remained in the programme – more than double average attendance rate for hospital-based rehabilitation. The average cost was estimated at £418 per participant which is within the National Health Service tariff for cardiac rehabilitation in England of £477 per patient. This NIHR-funded trial included 216 participants from four primary and secondary care centres across the UK. The home-based programme was facilitated by a trained cardiac nurse or physiotherapist via face-to-face and telephone sessions and included a choice of two home-based exercise programmes, a patient progress tracker and a caregiver resource. Despite the proven effectiveness of cardiac rehabilitation programmes in reducing readmissions and risk of death from heart disease, attendance varies widely across the UK and is generally poor.This home-based programme appears acceptable, affordable and safe, with higher levels of participation than have been seen previously in hospital-based programmes.
08 January 2019

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