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Welcome to the UK Clinical Trials Gateway

Thank you for visiting the UK Clinical Trials Gateway. We hope it gives you a clear understanding of what is involved if you participate in a clinical trial. You can search this site in various ways to find trials relevant to you and contact researchers yourself.

But, before doing any of this, you may have questions about trials, what they are and how they work. Indeed, you may have come to this site because your doctor has invited you to join a trial but you want to know more before you decide.

Taking part in medical research is a big step. It can potentially deliver great benefits to you or a loved one but it may also involve some inconvenience or risk. This site includes plenty of information about what a trial involves and what you can expect if you take part (more here).

We hope the general information about trials is useful. You may find that individual trial records contain complex scientific and medical terms and are hard to understand. We are working to address this (more here) and hope that you are able to find out what you need from the contact named on the trial record or from your own doctor.

We continue to introduce and test new features on the site and welcome your feedback and comments.If you have any general questions about the UKCTG website or suggestions about how we can improve it, please feel free to contact us at

Find trials near you.

Click on a location to see the trials running.

Latest research findings

from the NIHR Dissemination Centre

Statins are of no benefit in acute respiratory distress syndrome
Giving statins to patients with acute respiratory distress syndrome made no difference to the number of days they spent on a ventilator. It also had no effect on mortality or the length of time spent in intensive care or in hospital compared with placebo. In acute respiratory distress syndrome, the lungs become severely inflamed, fill with fluid (pulmonary oedema) and can no longer function. The person needs mechanical ventilation and is at high risk of multiple organ failure and mortality. This serious condition has high impact on both patients and NHS resources. Early studies had suggested statins may help to reverse the inflammatory process and could be a potential treatment to explore. This large, multicentre trial, funded by the NIHR, found no evidence that simvastatin (80mg daily) improved these outcomes. No practice change seems indicated.
13 March 2018

Pulmonary rehabilitation improves exercise tolerance in pulmonary fibrosis
People with idiopathic pulmonary fibrosis who received pulmonary rehabilitation could walk 44 metres further in six minutes than those who did no exercise. Quality of life also improved. Pulmonary fibrosis is a rare condition where scar tissue builds up in the lungs making them stiff and causing breathing difficulty. The term idiopathic means there is no known cause. It tends to get worse over time, reducing a person’s activity levels. Pulmonary rehabilitation is a core part of care, but most programmes were based on evidence in people with chronic obstructive pulmonary disease which is the commonest lung condition. This review looked at whether it improved outcomes for pulmonary fibrosis. Only five small trials were available, and there are some concerns about the quality of evidence. However, this may be the best evidence attainable. Programme content varied making it difficult to know which exercises help most and it’s unknown whether it affects prognosis. The review supports the use of pulmonary rehabilitation as currently recommended.
13 March 2018

Mat Pilates probably improves balance and strength in older adults
Mat Pilates appears to improve muscle strength, flexibility, balance and cardiovascular fitness in older people compared to no exercise. There are limitations to the reliability of the evidence, but the consistent effect across all the aspects of fitness suggests this is probably a useful option for the increasing number of older people who wish to maintain their fitness. This review pooled the results of nine trials of 415 older adults from around the world, though not the UK. Pilates sessions were attended at least twice weekly for four to 24 weeks. Guidelines recommend 150 minutes of moderate activity per week for older adults and two sessions of strength training. If at risk of falls, balance exercises such as yoga are recommended. This review indicates that Pilates would be a viable alternative that would improve both balance and strength. When taught by a qualified instructor and tailored to individual ability, Pilates is safe in this age group.
07 March 2018

More research news on clinical trials

Better healthcare starts with you

The UK Clinical Trials Gateway is designed to help you participate in clinical trials running in the UK.

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