UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studi... | Recruiting
UK Genetic Prostate Cancer Study: E... | Recruiting
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
UKGPCS

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Medical Conditions
  • Prostate Cancer
Primary Contact Details
Rosalind A Eeles, FRCP FRCR
02086613642
See all trial contact details
Recruitment Status
Recruiting
Trial source and source ID number
NCT01737242
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Summary
The UKGPCS was set up to find genetic alterations which occur in patients who have prostate cancer.

A man's risk of developing prostate cancer increases if he has a first-degree relative (father or brother) who was diagnosed with prostate cancer at a young age. This is why we are looking for men who are affected at a young age or who have a family history of prostate cancer, since it is more probable that these prostate cancers are due to an inherited genetic cause rather than an environmental cause.

We also ask all men who come to the Royal Marsden Hospital to be treated for prostate cancer if they would like to take part in the study so that we can also look to see if we find genetic alterations in older men, and those who do not have a family history of prostate cancer.
Research Details
  • The study is divided into two parts:

    1. The Study at The Royal Marsden NHS Foundation Trust, London and Sutton:

    The study will be offered to every patient attending the prostate clinics at The Royal Marsden NHS Foundation Trust, London and Sutton. This is called 'The Systematic Study'.

    Patients are approached in the clinic and are given an information sheet and the study is also explained verbally. They are asked for 18ml of blood and asked to fill out a family history and epidemiological questionnaire. Those who have not had any treatment will also be asked for 18ml blood for serum and plasma marker studies.

    Those patients with one relative affected with PrCa where one is ≤ 65 years at diagnosis or a total of 3 or more relatives with PrCa at any age, will be asked if their relatives can be approached to be asked to give a blood sample for DNA analysis for PrCa predisposition genes and tumour samples for molecular analyses for PrCa predisposition and behaviour as outlined above. Where relatives with PrCa are deceased, pathology records and tumour blocks will be requested after obtaining details of where they were treated via the index case.

    Consent Consent will be sought prospectively from living individuals accrued into the study from January 2006 to access medical records and tumour blocks.

    This study has been active since 1992 and all blood samples have informed consent for PrCa predisposition gene studies. Outside tumour blocks and pathological samples have informed consent for molecular studies. Many of The Royal Marsden NHS Foundation Trust PrCa tumour samples also have consent under a clause in the operation consent form in use at that time that 'material removed may be used for research purposes'. Some tissue was collected from local hospitals under the auspices of the previous protocol and the consent form did not explicitly state separate consent for the use of tissue at that time, although it was part of the approved protocol. Many patients are now deceased. It is therefore proposed that tissue and medical record data collected retrospectively will be analysed anonymously with no results fed back to patients as this would not impact upon their care. An exception is results from the studies on blood where findings in PrCa predisposition genes could have implications for relatives.

    Those patients who are still living who have previously taken part in the study from 1992 until the present and who have not taken part in the environmental questionnaire part of the study will be invited to take part in this part of the study. New consent will be obtained for this.

    2. The Study at Collaborative Centres throughout the UK. Many of these are via the NCRN network.

    This is conducted as for the Study at The Royal Marsden except the study is explained verbally and then if the patient is interested, their details are given to the study office by confidential fax and the study office sends the patient an information sheet and consent form.

    Furthermore, the only groups of patients eligible for this part of the study are (a) men with PrCa presenting at a young age (≤ 60 years) or (b) PrCa in first-degree related pairs where one is ≤ 65 years at diagnosis or (c) a total of 3 or more relatives with PrCa at any age

    The two parts (1) and (2) are now called the UKGPCS (UK Genetic Prostate Cancer Study).

    There are currently over 300 collaborators UK-wide participating under the auspices of the previous protocol (previously, The Cancer Research UK/British Prostate Group//British Association of Urological Surgeons Section of Oncology and NCRN Familial Prostate Cancer Study).

    Proposed analyses on the samples The samples will be used to find PrCa predisposition genes using linkage and other analyses. These investigations are solely for research to find a prostate cancer-predisposing gene and no results would be conveyed to the patients until such a gene(s) had been found. If such a gene(s) is found, then no patient will have genetic testing for abnormalities in such a gene without prior genetic counselling and this would be on a newly taken blood sample. Only those patients who wish (as stated on their consent form) to be informed of research findings will be contacted. If this occurs more than 6 months after the last contact with the patient, this would be via the GP.

    Data will be correlated with medical records and treatment outcome to find genetic alterations that are associated with prostate cancer development and/or prognosis.

    Tumour material will be collected and stored at -70oC in freezer space currently available at The Institute of Cancer Research. Tumour will also be stored in RNA later and paraffin embedded tumour will be made into tissue microarrays and sections cut. This will be used for molecular biology analysis.

    Cases and their relatives may be flagged by the cancer registry to confirm a diagnosis of prostate cancer, a date of death and cause of death. This will be done via the Medical Research Information Service (MRIS), using records maintained by The NHS Information Centre and the NHS Central Register.

    Clinical details are collected routinely as part of the medical care and clinical follow up record on patients with prostate cancer and these include disease parameters (e.g. stage, grade) and treatment outcome (e.g. survival data, side effects of treatment). We will also request follow-up data, approximately 2 years after the patient has consented, to record any relapse, treatment and survival data that has occurred since diagnosis. We will link the genetic findings with these clinical data to try to identify genetic markers of disease parameters (e.g. those which predict for poorer prognosis or worse late toxicity from treatments such as radiotherapy). These data would be analysed anonymously after linking the clinical and genetic datasets. No results would be feedback to participants. We will supply anonymised data from this to an EU dataset (Genepi study). This would only be to a central database managed under the auspices of GCP and would only be anonymised data. No individual would be identifiable to the holders of the Genepi database.
Phase
N/A
Study Design
Sorry, this information is not available
Study Type
Observational
Intervention
Sorry, this information is not available
Intervention Type
See Interventions above
Primary Outcome Measures
    To find genes which predispose to PrCa; 2017
Secondary Outcome Measures
    Sorry, this information is not available
Publication(s)
Sorry, this information is not available
Result Reports
Check availability of results on the Clinicaltrials.gov website
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Gender
Male
Age Range
N/A - N/A
Who Can Participate
Sorry, this information is not available
Number of Participants
26000
Participant Inclusion Criteria
    Inclusion Criteria:

    - Man with PrCa at any age at diagnosis at Royal Marsden NHS Foundation Trust

    - Those outside the Royal Marsden NHS Foundation Trust with

    - PrCa at or below 60 years at diagnosis

    - PrCa in first-degree related pairs where one is ≤ 65 years at diagnosis

    - PrCa at any age in a cluster with 3 or more cases

    - Those able to understand the information sheet and give informed consent (language line is available for those who wish to have translation)

    - Any unaffected relatives of men who are already taking part in the study

    Exclusion Criteria:

    - Man with PrCa who is too ill to take part
Participant Exclusion Criteria
This is in the inclusion criteria above
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Trial Location(s)
Royal Marsden - Surrey
Sutton
England
SM2 5PT
Trial Contact(s)
Primary Trial Contact
Rosalind A Eeles, FRCP FRCR
02086613642
Other Trial Contacts
Sorry, this information is not available
Countries Recruiting
United Kingdom
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Scientific Title
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
EudraCT Number
Not available for this trial
Funder(s)
  • Cancer Research UK
  • Royal Marsden NHS Foundation Trust
Other Study ID Numbers
06/MRE02/4
Sponsor(s)
Institute of Cancer Research, United Kingdom
Key Dates

Recruitment Start Date

Jan 1993

Recruitment End Date

Dec 2017

Trial Start Date
Date Not Available
Trial End Date
Date Not Available
Date added to source

27 Nov 2012

Date updated in source

12 Sep 2017