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Evaluation of the bioavailability of bioactive wheat bran components from b... | Not Recruiting
Evaluation of the bioavailability o... | Not Recruiting
Evaluation of the bioavailability of bioactive wheat bran components from bread rolls

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Medical Conditions
  • Chronic diseases, particularly cardiovascular disease and cancers
Primary Contact Details
Prof Robert Welch
+44 (0)28 7032 4205
See all trial contact details
Recruitment Status
Not Recruiting
Trial source and source ID number
ISRCTN27269236
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Summary
Not provided at time of registration
Research Details
  • Bioactive components present in processed wheat grain fraction enriched bread rolls are available to the body and can be detected in the plasma and urine shortly after consumption.
Phase
Not Specified
Study Design
Randomised within subject cross-over design on three occasions carried out in a single-centre
Study Type
Interventional
Intervention

1. Test-meal 1: 50 g wheat aleurone incorporated into a bread roll
2. Test-meal 2: 50 g wheat aleurone + 5.2 mg iron incorporated into a bread roll
3. Control-meal: 50 g refined wheat product incorporated into a bread roll

Test and control meals were balanced for energy, fibre and macronutrients.

Intervention Type
Drug
Primary Outcome Measures
    1. Changes in plasma betaine, choline, folate, tocopherols and ferulic acid attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours and 3 hours post-meal
    2. Changes in urinary ferulic acid attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours, 3 hours and 4 hours post-meal
Secondary Outcome Measures
    1. Changes in plasma antioxidant activity attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours and 3 hours post-meal
    2. Changes in urinary antioxidant activity and phenolic activity attributable to treatments, measured at baseline, 0.5 hours, 1 hour, 2 hours, 3 hours and 4 hours post-meal
    3. Evaluation of the effects of processing, including iron fortification, on the availability of the bioactive components in wheat fractions, using test-meal 2 and comparisons with previous work
Publication(s)
2015 results in http://www.ncbi.nlm.nih.gov/pubmed/25585164
Result Reports
Sorry, this information is not available
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Gender
Both
Age Range
Adult
Who Can Participate
Patient
Number of Participants
13 (6 males; 7 females)
Participant Inclusion Criteria
    Healthy 18 - 40 year old men and women with Body Mass Index (BMI) between 18 and 30 kg/m^2.
Participant Exclusion Criteria
    1. Smokers
    2. Individuals with diabetes
    3. Pre-existing chronic disease
    4. On any prescription medicine
    5. Individuals who regularly take any vitamin or mineral supplement or did so in the 6 months prior to the study
    6. Gluten or wheat intolerant individuals
    7. Pregnant or lactating women
    8. Individuals who have given blood to the Blood Transfusion Service (BTS) in the 4 months prior to the study
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Trial Location(s)
Coleraine
BT52 1SA
Trial Contact(s)
Primary Trial Contact
Prof Robert Welch
+44 (0)28 7032 4205
Other Trial Contacts
Sorry, this information is not available
Countries Recruiting
United Kingdom
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Scientific Title
Evaluation of the bioavailability of bioactive wheat bran components from bread rolls
EudraCT Number
Sorry, this information is not available
Funder(s)
  • HEALTHGRAIN (Europe) - an integrated 6th framework EU project (ref: FOOD-CT-2005-514008)
Other Study ID Numbers
N/A
Sponsor(s)
European Commission (Belgium)
Key Dates

Recruitment Start Date

01 Jan 2007

Recruitment End Date

31 Mar 2007

Trial Start Date

01 Jan 2007

Trial End Date

31 Mar 2007

Date added to source

04 Dec 2008

Date updated in source

04 Mar 2016