Renal protection against ischaemia-reperfusion in transplantation | Not Recruiting
Renal protection against ischaemia-... | Not Recruiting
Renal protection against ischaemia-reperfusion in transplantation
REPAIR
Trial Source

There is no location for this trial

Location data is sourced from multiple external providers and UKCTG is not responsible for and cannot guarantee the accuracy of data.

Medical Conditions
  • Kidney transplantation
Primary Contact Details
Not Recruiting
Recruitment Status
ISRCTN30083294
Primary Trial ID Number
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information, or it may still be awaited from the organisation running the trial. Please look again in a few days if the information you need is not here, or contact the researcher named above.
Summary
Not provided at time of registration
Research Details
  • Remote ischaemic preconditioning reduces ischaemia reperfusion injury to the kidney in living-donor transplantation and improves kidney function. Link to EME project website: http://www.eme.ac.uk/projectfiles/085202info.pdf Link to protocol: http://www.eme.ac.uk/projectfiles/085202protocol.pdf Please note that as of 04/08/10 this record has been updated to reflect changes to the exclusion criteria in the lastest protocol (v.7). Please see the revelant section for more details.
Phase
Sorry, this information is not available
Study Design
Double-blind factorial design randomised controlled trial
Study Type
Interventional
Intervention

The trial will test whether a simple procedure, the application of a blood pressure cuff to the arm of the donor and the recipient before a kidney transplant, can help protect the donor kidney from the harmful effects of the transplant. The blood pressure cuff to be used is similar to the one that is used to measure blood pressure. It will be inflated continuously for a five-minute period, after which it will be deflated for 5 minutes. This cycle of inflation, followed by deflation, will be performed 4 times in total. The trial follow up is 5 years, performed in the context of routine clinical follow up.

Intervention Type
Procedure/Surgery
Primary Outcome Measures
  • Glomerular filtration rate (GFR) 12 months after transplantation.
Secondary Outcome Measures
  • 1. Rate of fall in creatinine in the first 72 hours after transplantation
  • 2. Inflammatory response to surgery in the first 5 days after transplantation
  • 3. Protein expression in kidney parenchyma samples using histochemistry
  • 4. Protein activation and expression in renal vasculature using immunoblotting
  • 5. Kidney fibrosis 6 months after transplantation
  • 6. Alloreactivity of T-cells in the first 18 months after transplantation
  • 7. Patient outcomes 2 - 5 years after transplantation using renal registry data
Publication(s)
2015 results in: http://www.ncbi.nlm.nih.gov/pubmed/26020087
Result Reports
Sorry, this information is not available
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information, or it may still be awaited from the organisation running the trial. Please look again in a few days if the information you need is not here, or contact the researcher named above.
Gender
Both
Age Range
Adult
Who Can Participate
Patient
Number of Participants
400
Participant Inclusion Criteria
  • 1. Patients undergoing living donor transplantation
  • 2. Patients aged 18 years and above, either sex
Participant Exclusion Criteria
  • 1. 0,0,0-mismatched renal grafts (no mismatch in HLA-A/B/DR antigens between donor and recipient)
  • 2. Patients on adenosine triphosphate (ATP)-sensitive potassium channel opening or blocking drugs
  • 3. Patients on ciclosporin
  • 4. Patients who have had a previous transplant
  • 5. Patients with a known iodine sensitivity (who cannot undergo iohexol clearance studies)
  • Added 04/08/2010:
  • 6. Patients with ABO incompatability
  • 7. Any patient requiring HLA antibody removal therapy
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information, or it may still be awaited from the organisation running the trial. Please look again in a few days if the information you need is not here, or contact the researcher named above.
Trial Location(s)
London
WC1E 6JJ
Trial Contact(s)
Primary Trial Contact
Prof Raymond MacAllister
-
Other Trial Contacts
Sorry, this information is not available
Countries Recruiting
Netherlands, United Kingdom
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information, or it may still be awaited from the organisation running the trial. Please look again in a few days if the information you need is not here, or contact the researcher named above.
Scientific Title
Renal protection against ischaemia-reperfusion in transplantation: a double-blind randomised controlled trial with a factorial design
EudraCT Number
Sorry, this information is not available
Funder(s)
  • Medical Research Council (MRC)/National Institutes of Health Research (NIHR) (UK) - Efficacy and Mechanism Evaluation (EME) Programme (ref: EME 08/52/02)
Other Study ID Numbers
EME 08/52/02; 2 version 7
Sponsor(s)
University College London (UCL) (UK)
Key Dates

Recruitment Start Date

30 Sep 2009

Recruitment End Date

31 Mar 2013

Trial Start Date

30 Sep 2009

Trial End Date

31 Mar 2013

Date Assigned

08 Jul 2009

Last Updated

28 May 2015

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