Nottingham Osteoarthritis Biomarker Study 2011 | Completed
Nottingham Osteoarthritis Biomarker... | Completed
Nottingham Osteoarthritis Biomarker Study 2011

Trial Source

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Medical Conditions
  • Osteoarthritis
Unfortunately contact details are not available for this trial.
Primary Contact Details
Completed
Recruitment Status
NCT01495455
Primary Trial ID Number

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Summary
Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that influence its development and progression. Identification of biochemical markers that relate to cartilage loss, bony overgrowth and other features that occur with osteoarthritis will advance our understanding. Over the last 5 years analytical methods have developed to measure a range of different biomarkers. This pilot study will use these analytical methods to measure biomarker levels in joint fluid, urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers.

This study will provide novel pilot data on the changes in the composition of the synovial fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the knee is a suitable joint for study because of its accessibility to clinical assessment, joint aspiration and imaging.
Research Details
    Sorry, this information is not available
Phase
N/A
Study Design
Observational Model: Case Control, Time Perspective: Cross-Sectional
Study Type
Observational
Intervention
Sorry, this information is not available
Intervention Type
See Interventions above
Primary Outcome Measures
    Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees.; within 6 months of recruitment of last participant
Secondary Outcome Measures
    Sorry, this information is not available
Publication(s)
Sorry, this information is not available
Result Reports
Check availability of results on the Clinicaltrials.gov website
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Gender
Both
Age Range
30 Years - N/A
Who Can Participate
Sorry, this information is not available
Number of Participants
Sorry, this information is not available
Participant Inclusion Criteria
    Inclusion Criteria:

    All participants:

    - Be able to provide written informed consent

    - Aged 30 and over

    Knee OA patients:

    • Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at least one compartment of the knee

    Normal controls:

    - No knee pain

    - No clinical or radiographic changes of knee OA
Participant Exclusion Criteria
This is in the inclusion criteria above
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Trial Location(s)
Nottingham
Nottinghamshire
NG5 1PB
Trial Contact(s)
Primary Trial Contact
Sorry, this information is not available
Other Trial Contacts
Sorry, this information is not available
Countries Recruiting
United Kingdom
This information is designed to help you decide whether this trial is of interest. In some cases it is provided as a link to more detailed patient information or it may still be awaited from the organisation running the trial. Please look again shortly if the information you need is not here or, if named, contact the researcher named above.
Scientific Title
Nottingham Osteoarthritis Biomarker Study 2011
EudraCT Number
Not available for this trial
Funder(s)
    Sorry, this information is not available
Other Study ID Numbers
11049
Sponsor(s)
University of Nottingham
Key Dates

Recruitment Start Date

Feb 2012

Recruitment End Date

Jan 2013

Trial Start Date
Date Not Available
Trial End Date
Date Not Available
Date Assigned

30 Nov 2011

Last Updated

29 Jan 2013